The pharmacotherapy specialist-directed research team in a large healthcare system plans to submit a comparative effectiveness study proposal in response to the request for proposals released under the Patient Protection and Affordable Care Act. In designing this study, which category of outcomes should be used for the primary endpoint?
An article in a clinical pharmacology journal describes a double-blind controlled trial comparing the efficacy of sumatriptan to a placebo injection for intractable migraine which used a 5 point Likert scale to evaluate headaches 2 hours after treatment. Which of the following is the most appropriate statistical test for analyzing the data?
A patient with renal failure is being treated with phenytoin and has an albumin concentration of
1.7 g/dL. Which of the following is likely to be higher than the general population in this patient?
A mother mistakenly gives her 2-year-old child 1 tablespoon of albuterol sulfate (2 mg/5mL) instead of 1 teaspoon. The child experiences no harm from the extra amount. Which statement is correct?
A 53-year-old patient is admitted to the hospital with diarrhea. He has been experiencing five unformed stools daily for 2 days. The patient had a previous admission 6 weeks ago for C.
difficile diarrhea, which was treated successfully with oral metronidazole. Stool tests are again positive for C. difficile toxin A.
On presentation, his vital signs are: BP 128/86 mm Hg, HR 75 bpm, RR 14 bpm, and T37.8°C.
WBC count shows 12,300 cells/ul (80% neutrophils-segs, 10% neutrophils-bands), serum creatinine 1.2 mg/dL, and albumin 3.4 g/dL. The patient has no evidence of colitis, toxic megacolon, or perforation on imaging studies of the abdomen.
What is the most appropriate treatment recommendation for this patient?
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