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  1. Home
  2. NABP Certification
  3. NAPLEX Exam
  4. NABP.NAPLEX.v2024-01-24.q78 Dumps
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Question 66

What is the standard loading dose for clopidogrel in the treatment of ACS?

Correct Answer: E
Explanation
300mg is the standard loading dose of clopidogrel - an antiplatelet drug - in the treatment of acute coronary syndrome (ACS).
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Question 67

What is the Osmolarity of NS with KCL 40 meq/L? (MW of KCl: 74.55 g/mol) (MW of NaCl: 58.44 g/mol)

Correct Answer: E
KCl: Osmoles = number of particles in solution Convert 40meq to weight in g: 40meq × 1equiv/1000 mEq ×
74.5g/1 equiv = 2.98g of KCL. Calculate mOsm/L: 2.98g/L × 1mol/74.5g × 2Osm/1 mol × 1000mOsm/1 Osm
80mOsm/L. NaCl: 0.9g/100ml × 1mol/58.5 g × 2 Osm/1mol × 1000 mOsm/ 1Osm × 1000ml/1L = 308 mOsm/L
80 mOsm/L + 308 mOsm/L = 388 mOsm/L
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Question 68

Which of the following antidiabetic medication works by decreasing glucose reabsorption?

Correct Answer: E
Explanation
Empagliflozin is a SGLT2 inhibitor to decrease glucose reabsorption in the kidney. Linagliptin is a DPP-4 inhibitor that works on incretins/increase insulin secretion/decrease glucagon secretion. Pioglitazone is a TZD that increases insulin sensitivity. Exenatide is a GLP-1 agonist which increase insulin secretion/decrease glucagon secretion/increase satiety.
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Question 69

Your patient is a 43-year-old male who is experiencing post-operative voiding difficulty after an elective inguinal hernia repair. His post void residual volume was 280 cc.
Which of the following medications is the most appropriate choice of therapy for this patient?

Correct Answer: A
Explanation
The patient is experiencing a common complication of low abdominal surgery. Post-operative urinary retention occurs in almost 25% of patients after low abdominal surgical procedures. A normal post-void residual volume is less than 50 cc or urine. The effects of anesthesia and analgesia both contribute to bladder distension, decreased micturition reflex, reduction of contractility of the detrusor muscle of the bladder, and incomplete voiding. The detrusor muscle of the bladder is stimulated to contract by muscarinic cholinergic agonists. Bethanechol is a muscarinic agonist and is frequently used in this setting to improve bladder emptying. Finasteride is a drug that is a 5 alpha reductase inhibitor indicated for use in patients with bladder outlet obstruction as a result of prostatic hypertrophy. The inhibition of 5 alpha reductase decreases local conversion of testosterone to dihydrotestosterone in the prostate gland, which results in gradual shrinkage over a period of six to twelve months. Phenylephrine is an alpha-adrenergic agonist that is selective for alpha-1 receptors. Activation of the alpha 1 receptors in the bladder results in contraction of the trigone muscle and sphincter.
This promotes urinary retention. Oxybutynin is an antimuscarinic agent that is useful for treatment of urge incontinence, and would have a detrimental effect on this patient's bladder disorder. Imipramine is a medication with anticholinergic properties that would also cause worsening of the patient's condition. Take home message: Post-operative urinary retention with concomitant incomplete voiding is a complication that results from a decreased micturition reflex, increased vesical sphincter tone, or decreased contractility of the detrusor muscle of the bladder. It can be successfully treated with a muscarinic agonist, such as bethanechol, or with an alpha-1 adrenergic antagonist.
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Question 70

You get an order for 5% amino acid 15% dextrose premixed parenteral nutrition solution, 2 L at 83mls/hr.
Your pharmacy technician tells you there is manufacture's backorder on those. How many ml of 20% dextrose would you need to provide the same amount of dextrose in 24 hrs?

Correct Answer: C
Explanation
15% dextrose = 15gm/100ml = 300gm/2000ml. Patient needs 300gm. 300gm/Xml = 20gm/100ml = 1500ml
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