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NABP Certification
NAPLEX Exam
NABP.NAPLEX.v2024-01-24.q78 Dumps

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Question 1

In Normal distribution, what percentage of the sample is found within 2 standard deviation of the mean?

A.68%
B.95%
C.99%
D.100%
E.72%

Correct Answer: B

Explanation
In a normal distribution sample, within 1 standard deviation 68% of the sample falls within 1 standard deviation, 95% within 2 standard deviations, and 99.7% within 3 standard deviations of the mean.

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Question 2

Which of the following beta-blocker is NOT proven to reduce mortality in patients with Systolic CHF?

A.Bisoprolol
B.Nadolol
C.Carvedilol
D.Metoprolol succinate
E.Metoprolol Tartrate

Correct Answer: E

Nadolol is not proven to reduce mortality in patients with systolic CHF. The efficacy of nadolol in HF has not been determined. For patients taking nadolol, it should be used with caution in those with compensated heart failure and patients should be monitored for a worsening of the condition. Bisoprolol, carvedilol, and sustained- release metoprolol succinate are the beta-blockers that have been proven to reduce mortality in patients with systolic CHF. These 3 beta-blockers have been effective in reducing the risk of death in patients with chronic HFrEF. Other beta-blockers were found to be less effective. Bucindolol did not exhibit uniform effectiveness across different populations. Metoprolol tartrate was found to be less effective in HF clinical trials.
Reference:
http://circ.ahajournals.org/content/128/16/e240

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Question 3

Aluminum levels may rise to toxic levels in patients with renal failure if administered with which of these medicines?

A.Sucralfate
B.Bismuth subgallate
C.Docusate sodium
D.Lactulose
E.Alginates

Correct Answer: A

Explanation
Sucralfate is a drug used to treat active duodenal ulcers and may also be used to treat GERD or stress ulcers.

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Question 4

Which of the following represents the major route of metabolism for acetaminophen?

A.Glucuronidation
B.Sulfation
C.Cytochrome P-450 oxidation
D.Direct renal excretion
E.Plasma breakdown

Correct Answer: A

Explanation
Acetaminophen is metabolized by choices A through D.
The major route is glucuronidation catalyzed by UDP- glucuronyl transferase in the liver. Sulfation is the next most common route and is the target mechanism for NAC therapy. Oxidation by cytochrome P-450 results in the formation of N-acetyl-p-benzoquinone imine, which is responsible for the hepatic necrosis caused by acetaminophen overdose. Direct renal excretion represents approximately 5% of the metabolism of acetaminophen. Plasma metabolism of acetaminophen does not generally occur.

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Question 5

What is the mechanism of action of the active ingredient found in Zyflo?

A.Ultra-long-acting beta-2 agonist
B.5-lipogenase inhibitor
C.Leukotriene D4 inhibitor
D.Long-acting anticholinergic

Correct Answer: B

Explanation
Zileuton is the active ingredient found in the medicine Zyflo; a medicine that works as a 5-lipoxygenase inhibitor. As such, zileuton inhibits leukotrienes (LTB4, LTC4, LTD4, and LTE4) formation, and is used for the maintenance treatment of asthma in patients older than the age of 12. In 2 percent of patients, it raises liver enzymes. Sinusitis and nausea are the most common side effects.

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