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  1. Home
  2. NABP Certification
  3. NAPLEX Exam
  4. NABP.NAPLEX.v2022-04-12.q74 Dumps
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Question 26

What is the active ingredient found in the medicine Adalat?

Correct Answer: A
Explanation
The dihydropyridine drug - nifedipine - is the active ingredient found in the medicine Adalat. Nifedipine is used to treat angina, Reynaud's phenomenon and hypertension. It is also used as a tocolytic agent in premature labor.
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Question 27

Which of the following statements is true regarding Drug-receptor bonds?

Correct Answer: E
Explanation
Drugs mainly interact with the receptors by means of chemical forces or bonds. There are three major types of drug receptor bonds: - Covalent - Electrostatic - Hydrophobic Covalent bonds are very strong bonds and in most of the cases they are irreversible under biologic conditions. For example, the covalent bond between the acetyl group of aspirin and cyclo-oxygenase enzyme (target enzyme present on the platelets) does not breaks easily. The platelet aggregation effect of aspirin lasts long after free acetyl-salicylic acid has disappeared from the blood (about 15 minutes) and it is reversed only by the synthesis of new cyclo-oxygenase enzyme in new platelets which takes a long time. Hence the effect of aspirin is seen after the drug is stopped. Among the drug receptor interactions, electrostatic bond is much more commonly found than covalent bond. The electrostatic bonds vary from relatively strong linkages between permanently charged ionic molecules to weaker hydrogen bonds and very weak induced dipole interactions such as van der Waals force. The electrostatic bonds are weaker than covalent bonds. Hydrophobic bonds are usually very weak bonds and probably important in the interactions of highly lipid soluble drugs with the lipids of cell membranes and perhaps in the interactions of the drugs with the internal walls of receptor "pockets".
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Question 28

If LN receives Dextrose 5% half Normal Saline with 20 meq of Potassium as IVF at 125mls/hour. How much dextrose is he getting in 24hrs?

Correct Answer: D
Explanation
0.05 (1000 mL) = 50 g 1000 mL * (1 hour/125 mL) = 8 hours 50 * 3 = 150 g
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Question 29

The rate that an outcome will occur given a particular exposure, compared to the rate of the outcome occurring in the absence of that exposure is definition of which of the following?

Correct Answer: D
Explanation
RR = rate of an outcome occurring in an exposed group (treatment group/intervention group) divided by the rate of an outcome occurring in an unexposed group (control group) Ex: Relative Risk = Rate of UTI in patients taking drug XYZ / rate of UTI in patients not on drug XYZ
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Question 30

Which of the following medication should be avoided in patients with heart failure?

Correct Answer: E
Patients with heart failure should avoid taking NSAIDs (which includes naproxen), COX-2 inhibitors, nondihydropyridine calcium channel blockers (for reduced EF), thiazolidinediones (which includes pioglitazone), cilostazol, and dronedarone (for severe or recently decompensated heart failure).
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